Patrick F., Sullivan Franzcp and Tobias Allander
The recent debate regarding the possible involvement of xenotropic murine leukemia virus-related virus
(XMRV) in chronic fatigue syndrome (CFS) in humans has been intense due to the conflicting results
from different studies and the unclear origin of the XMRV virus. In this study, we have addressed this
issue by screening 47 pairs of monozygotic twins discordant for CFS using a sensitive PCR assay. The
results are clearly negative for all samples. This is consistent with studies showing no evidence for the
involvement of XMRV in CFS and supports the possibility that previous positive studies could be
caused by laboratory artifacts.
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